Abstract Background CJ9-gD is a novel dominant-negative recombinant herpes simplex virus type 1 (HSV-1) that is completely replication-defective, cannot establish detectable latent caruso rhodiola infection in vivo, and expresses high levels of the major HSV-1 antigen glycoprotein D immediately following infection.In the present study, CJ9-gD was e
An anthropological trauma analysis was conducted on an individual killed by multiple injuries from a combined sharp and blunt mechanism using a cold wella color charm 050 cooling violet weapon (machete) to the head, trunk and upper extremities.After conducting the autopsy, the cranial fragments were submitted to the anthropology laboratory for clea
Recent analyses of amino acid mutations in proteins reveal that mutations at many pairs of sites are epistatic-i.e., their effects on fitness are non-additive-the combined effect of two mutations being significantly larger or smaller than the sum of their effects considered independently.Interestingly, epistatic sites are not necessarily near each
Early life stress (ELS) causes long-lasting changes in brain plasticity induced by the exposure to stress factors acting prenatally or in the early postnatal ontogenesis due to hyperactivation of here hypothalamic-pituitary-adrenal axis and sympathetic nervous system, development of neuroinflammation, aberrant neurogenesis and angiogenesis, and sig